Table 1 The kinetic parameters of Bufalin and ESR1, CYP17A1, and PKC delta binding from SPRi

From: Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha

Protein

Avg ka (1/Ms)

Avg kd (1/s)

Avg KD (M)

ABS (tr_KD)

ESR1

1.29E + 02

6.98E−04

5.42E−06

17.492

CYP17A1

2.50E + 00

7.36E−02

2.94E−02

5.086

PKC delta

1.79E + 01

2.31E−01

1.29E−02

6.271

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