Fig. 1: Ribosomal RNA methyltransferases regulate lifespan, heat, and UV stress response.
From: The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life
a–c Directed RNAi screen of putative rRNA methyltransferases reveals changes in a lifespan, b UV stress survival, and c heat stress survival relative to empty vector control worms. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Each dot represents an independent experiment with 30 worms per plate in three plates. One-way ANOVA with Dunnett’s multiple comparisons was used to calculate statistics within a single experiment for stress assays, and log-rank (Mantel–Cox) test were performed for longevity assays. Fisher’s combined method was used to calculate p values across multiple independent experiments. All columns represent the mean ± SEM (a) or SD (b, c). Some RNAi clones were not replicated (without error bars) due to no effect being observed.
