Fig. 2: Ribosomal RNA modifications in 26S and 18S are dynamically regulated throughout life and change in response to UV and heat stress.
From: The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life
a 26S and 18S rRNA extracted from C. elegans at different ages, from 4 days to 19 days, reveal changes in rRNA methylation as assessed by UHPLC-ms/ms. This heat map represents the relative changes of methylation in 4 biological replicates. Changes in individual modifications can be seen in Fig. S2C. b, c 26S and 18S rRNA extracted from C. elegans after UV stress (b) or 37 °C heat stress (c) relative to worms not exposed to UV (ctl) or grown at 20 °C reveal some changes in rRNA methylation as assessed by UHPLC-ms/ms. These heatmaps represent the relative changes of methylation in three biological replicates. Changes in individual modifications can be seen in Supplementary Fig. 2e, f.
