Fig. 3: Simulations of IBD estimation in different geographic areas using the microhaplotype panel.
From: Microhaplotype deep sequencing assays to capture Plasmodium vivax infection lineages
Root mean square error (RMSE) of relatedness estimates based on data simulated using nine different data-generating relatedness estimates, r (specifically IBD of 0.01 [essentially unrelated], 0.05 [very low related], 0.1 [low related], 0.15 [low related], 0.2 [low related], 0.25 [half-sibling], 0.5 [sibling], 0.75 [highly related], and 0.99 [essentially clonally identical]) with switch rate parameter k set to 5. Data were generated using paneljudge software on 91 high performance microhaplotypes in independent infections from each population (see sample sizes within the figure). In all populations, half-siblings and siblings had the highest RMSE, but this remained below 0.12 in all cases. Each country is presented in a different colour.
