Fig. 1: IBS-D induces intestinal motility disorders and disturbances in drug absorption. | Nature Communications

Fig. 1: IBS-D induces intestinal motility disorders and disturbances in drug absorption.

From: Microalgae-based Intestinal villi-targeting multistage biosystem for irritable bowel syndrome treatment

Fig. 1

a, b Functional enrichment of KEGG pathways for the differentially expressed genes in the PIBD group (a) and the IBS-D group (b). Modified t-test of the limma package (which combines empirical Bayesian variance adjustment) was used for comparisons between two groups. c MY Powder and MY@Cap preparation. d Representative MRM mass spectrometry chromatogram of MY. e Blood MY concentration in each group (n  =  3 biologically independent animals). f Ex vivo distribution of FITC fluorescence in each group at 4 h after gavage. g SEM (pseudo-color) of gut after taking oral SP, scale bar = 20 µm. h Schematic illustration of engineered microalgae multistage biosystem. The data show means + SD. PLGA poly(lactic-co-glycolic acid); PVA polyvinyl alcohol; MY myricetin; CS chitosan; SP spirulina platensis; SIBO small intestinal bacterial overgrowth. Source data are provided as a Source Data file.

Back to article page