Fig. 1: IAV infection induces conserved transcriptional changes at day 10 and 40 post infection. | Nature Communications

Fig. 1: IAV infection induces conserved transcriptional changes at day 10 and 40 post infection.

From: Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge

Fig. 1

RNA sequencing was performed on sorted lung epithelial cells, fibroblasts, and blood endothelial cells (BEC) from naive and C57BL/6 mice infected with influenza A virus (IAV) 10 (A, B) or 40 (C, D) days previously. A, C Differentially expressed genes (DEG) with a twofold change and a False Discovery Rate q value < 0.05 in lung structural cells were considered statistically significant. 7–8 mice were combined to make four samples per timepoint. B, D Volcano plots show the relationship between the fold change and the associated p value with the top 10 DEG by fold change. E Venn diagrams showing overlap between differentially expressed upregulated genes at day 10 and 40 post IAV infection. Source data in E are provided as a Source Data file.

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