Fig. 6: Loss of MacroD1 alters the abundance of metabolic proteins and increases glucose consumption and insulin sensitivity.
From: MacroD1 sustains mitochondrial integrity and oxidative metabolism
A The whole proteome from the hind limb muscle of MacroD1−/− and wildtype mice was analyzed via mass spectrometry. Significantly altered proteins are highlighted in red (any significantly changed protein) or blue (highlighted changed proteins). B STRING analysis of significantly downregulated proteins. C, D MacroD1−/− (KO) and wildtype (WT) mice were starved for 16 h (C) or 4 h (D), and glucose (C) and insulin tolerance tests (D) were performed. Data is shown as mean ± SD from n = 6–8 individual mice. For statistical analysis of C, D, a two-way ANOVA with Geisser-Greenhouse correction as performed (*, p < 0.05; **p < 0.005; ***p < 0.0005) on data from n = 14 –15 (C) and 6–8 (D) individual mice. Source data are provided as a Source Data file.
