Fig. 4: Plasma metabolome displays sex specific effects of fasting and energy restriction in 3xTg-AD mice. | Nature Communications

Fig. 4: Plasma metabolome displays sex specific effects of fasting and energy restriction in 3xTg-AD mice.

From: Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease

Fig. 4

Targeted metabolomics were performed on the plasma of female and male 3xTg mice fed ad libitum (AL), Diluted AL (DL) or Caloric Restricted (CR with fasting between once-daily meals) diets. Principal Component Analysis (PCA) of plasma metabolites from 3xTg females (A) and males (C) fed on an AL, DL or CR diets. Heatmap of 47 targeted metabolites, represented as log2-fold change vs. AL-fed mice in females (B) and males. (D). B *p < 0.05 vs. AL-fed mice, two-tailed Tukey’s test post ANOVA. A–D For females n = 5 AL, n = 6 DL, n = 6 CR biologically independent mice per group were used. For males n = 4 AL, n = 3 DL, n = 5 biologically independent mice per group were used. Source data are provided as a Source Data file.

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