Fig. 5: Overlapping brain metabolome profile in female 3xTg-AD mice under energy restriction and once-per-day CR regimen. | Nature Communications

Fig. 5: Overlapping brain metabolome profile in female 3xTg-AD mice under energy restriction and once-per-day CR regimen.

From: Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease

Fig. 5

Targeted metabolomics were performed on the brain of female and male 3xTg mice fed ad libitum (AL), Diluted AL (DL) or Caloric Restricted (CR with fasting between once-daily meals) diets. Principal Component Analysis (PCA) of plasma metabolites from 3xTg females (A) and males (C) fed on an AL, DL or CR diets. (B, D) Heatmap of 47 targeted metabolites, represented as log2-fold change vs. AL-fed mice in females (B) and males (D). B, D *p < 0.05 vs. AL-fed mice, two-tailed Tukey’s test post one-way ANOVA. A–D For females n = 6 biologically independent mice per group were used. For males n = 6 AL, n = 5 DL, n = 6 biologically independent mice per group were used. Source data are provided as a Source Data file.

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