Table 2 Commonly regulated genes in sCap from IPF samples and from BLM model
From: Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice
Gene | Description | Expression in fibrosis |
|---|---|---|
ACKR4 | atypical chemokine receptor 4 | downregulated |
ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif 7 | upregulated |
ADRB2 | adrenoceptor beta 2 | downregulated |
ANKRD33B | ankyrin repeat domain 33B | downregulated |
APLNR | apelin receptor | upregulated |
APRT | adenine phosphoribosyltransferase | upregulated |
BACE2 | beta-secretase 2 | upregulated |
BDKRB2 | bradykinin receptor B2 | upregulated |
CAMK1 | calcium/calmodulin dependent protein kinase I | downregulated |
CD34 | CD34 molecule | upregulated |
CDA | cytidine deaminase | upregulated |
CDKN1B | cyclin dependent kinase inhibitor 1B | downregulated |
CEBPB | CCAAT enhancer binding protein beta | downregulated |
CLK4 | CDC like kinase 4 | downregulated |
COL15A1 | collagen type XV alpha 1 chain | upregulated |
COL18A1 | collagen type XVIII alpha 1 chain | upregulated |
COL4A1 | collagen type IV alpha 1 chain | upregulated |
COL4A2 | collagen type IV alpha 2 chain | upregulated |
COTL1 | coactosin like F-actin binding protein 1 | upregulated |
DBN1 | drebrin 1 | upregulated |
DDHD2 | DDHD domain containing 2 | downregulated |
DNAJB1 | DnaJ heat shock protein family (Hsp40) member B1 | downregulated |
EEF1B2 | eukaryotic translation elongation factor 1 beta 2 | upregulated |
ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 | downregulated |
EPAS1 | endothelial PAS domain protein 1 | downregulated |
EPB41 | erythrocyte membrane protein band 4.1 | downregulated |
EVL | Enah/Vasp-like | upregulated |
FKBP10 | FKBP prolyl isomerase 10 | upregulated |
FXN | frataxin | upregulated |
GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | upregulated |
GATA2 | GATA binding protein 2 | downregulated |
GFOD1 | Gfo/Idh/MocA-like oxidoreductase domain containing 1 | downregulated |
GJA1 | gap junction protein alpha 1 | upregulated |
GPATCH4 | G-patch domain containing 4 (gene/pseudogene) | upregulated |
GPIHBP1 | glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 | downregulated |
HCLS1 | hematopoietic cell-specific Lyn substrate 1 | upregulated |
HIF1A | hypoxia inducible factor 1 subunit alpha | upregulated |
HIPK2 | homeodomain interacting protein kinase 2 | downregulated |
HLA-E | major histocompatibility complex, class I, E | downregulated |
HOXA5 | homeobox A5 | downregulated |
IGFBP7 | insulin like growth factor binding protein 7 | upregulated |
INHBB | inhibin subunit beta B | upregulated |
JUN | Jun proto-oncogene, AP-1 transcription factor subunit | downregulated |
KCNJ15 | potassium inwardly rectifying channel subfamily J member 15 | upregulated |
KLF2 | KLF transcription factor 2 | downregulated |
KLF3 | KLF transcription factor 3 | downregulated |
KLF4 | KLF transcription factor 4 | downregulated |
LAMA4 | laminin subunit alpha 4 | upregulated |
LAMC1 | laminin subunit gamma 1 | upregulated |
LIMS2 | LIM zinc finger domain containing 2 | downregulated |
LMNB1 | lamin B1 | upregulated |
MAP1B | microtubule associated protein 1B | upregulated |
MCC | MCC regulator of WNT signaling pathway | downregulated |
MEOX1 | mesenchyme homeobox 1 | upregulated |
METTL1 | methyltransferase 1, tRNA methylguanosine | upregulated |
MRTO4 | MRT4 homolog, ribosome maturation factor | upregulated |
MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like | upregulated |
MYO1B | myosin IB | upregulated |
NCOA3 | nuclear receptor coactivator 3 | downregulated |
NKTR | natural killer cell triggering receptor | downregulated |
NME1 | NME/NM23 nucleoside diphosphate kinase 1 | upregulated |
NOP16 | NOP16 nucleolar protein | upregulated |
NPM3 | nucleophosmin/nucleoplasmin 3 | upregulated |
NR5A2 | nuclear receptor subfamily 5 group A member 2 | upregulated |
NREP | neuronal regeneration related protein | upregulated |
NRGN | neurogranin | upregulated |
P2RY6 | pyrimidinergic receptor P2Y6 | upregulated |
PAFAH1B3 | platelet activating factor acetylhydrolase 1b catalytic subunit 3 | upregulated |
PDLIM4 | PDZ and LIM domain 4 | upregulated |
PLPP2 | phospholipid phosphatase 2 | upregulated |
PPP1R14B | protein phosphatase 1 regulatory inhibitor subunit 14B | upregulated |
PPP1R15A | protein phosphatase 1 regulatory subunit 15A | downregulated |
PRR5L | proline rich 5 like | upregulated |
PTPRB | protein tyrosine phosphatase receptor type B | downregulated |
RAB13 | RAB13, member RAS oncogene family | upregulated |
RAI14 | retinoic acid induced 14 | upregulated |
RHOD | ras homolog family member D | upregulated |
RPL10A | ribosomal protein L10a | upregulated |
RPL22L1 | ribosomal protein L22 like 1 | upregulated |
RPS18 | ribosomal protein S18 | upregulated |
RPS3 | ribosomal protein S3 | upregulated |
RPS6 | ribosomal protein S6 | upregulated |
RUNX1T1 | RUNX1 partner transcriptional co-repressor 1 | downregulated |
SECISBP2L | SECIS binding protein 2 like | downregulated |
SEMA6B | semaphorin 6B | upregulated |
SH2B2 | SH2B adaptor protein 2 | upregulated |
SHE | Src homology 2 domain containing E | downregulated |
SKIL | SKI like proto-oncogene | downregulated |
SMAD3 | SMAD family member 3 | upregulated |
SMAD7 | SMAD family member 7 | downregulated |
SMOX | spermine oxidase | upregulated |
SNX18 | sorting nexin 18 | downregulated |
SPRY1 | sprouty RTK signaling antagonist 1 | upregulated |
SRM | spermidine synthase | upregulated |
ST6GALNAC3 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | downregulated |
STK4 | serine/threonine kinase 4 | downregulated |
SYNE1 | spectrin repeat containing nuclear envelope protein 1 | downregulated |
SYNPO | synaptopodin | upregulated |
TEK | TEK receptor tyrosine kinase | downregulated |
THBS1 | thrombospondin 1 | upregulated |
TLE4 | TLE family member 4, transcriptional corepressor | downregulated |
TMEM50B | transmembrane protein 50B | downregulated |
TMTC1 | transmembrane O-mannosyltransferase targeting cadherins 1 | downregulated |
TRIB1 | tribbles pseudokinase 1 | upregulated |
TSHZ2 | teashirt zinc finger homeobox 2 | upregulated |
TSPAN5 | tetraspanin 5 | upregulated |
TYMS | thymidylate synthetase | upregulated |
UBTD1 | ubiquitin domain containing 1 | upregulated |
UCK2 | uridine-cytidine kinase 2 | upregulated |
VWA1 | von Willebrand factor A domain containing 1 | upregulated |
ZMYND11 | zinc finger MYND-type containing 11 | downregulated |
ZNF593 | zinc finger protein 593 | upregulated |
