Fig. 1: Circulating lipids are altered with age in humans and mice. | Nature Communications

Fig. 1: Circulating lipids are altered with age in humans and mice.

From: 12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII

Fig. 1

Plasma lipid profiles of young (18–35 year old) and older (65–90 year old) humans displayed as a heat map, b principal component analysis, and c volcano plot. Plasma lipid profiles of young (3 months old) and older (24 months old) male mice displayed as d heat map, e principal component analysis, and f volcano plot. Quantification of 12,13-diHOME in g humans (green: young, red: aged) and h mice (dotted green: young, dotted red: aged). Humans n = 7 and 12 per group. Mice n = 7 per group. Data are expressed as mean ± SEM. Volcano plot shows the log2 fold change versus –log10 (p) value from two-sided Student’s t tests. False discovery rate (FDR) correction was applied, with significance threshold set at FDR < 0.05 (c, f). Two-tailed P values by unpaired Student’s t test (g, h).

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