Fig. 7: Higher levels of IL6 indicates poor prognosis in NPC.
From: PROCR diminishes the efficacy of radiation by impairing T-cell-mediated antitumour immunity
A Representative images of IHC staining for PROCR and IL6 expression in NPC tissue samples. Scale bar, 50 μm. B Correlation analysis of PROCR expression and IL6 detected by IHC. n = 44 independent experiments. The P value was determined using the two-tailed χ2 test. C Correlation analysis of IL6 expression and locoregional recurrence status after radical chemoradiotherapy. n = 220 independent experiments. The P value was determined using the two-tailed χ2 test. Kaplan–Meier analysis of overall survival (D) and disease-free survival (E) based on the IL6 expression level. The analysis includes 102 patients in the IL-6 low group and 118 patients in the IL-6 high group. The P values were determined using the log-rank test. F Proposed working model of PROCR. Mechanistically, PROCR engages Src kinase to transactivate IGF-1R, leading to the activation of ERK and RSK1, which enhances IL-6 secretion through NFκB pathway and inhibits Th1 and CD8+CTL differentiation. PROCR is degraded by p62-mediated selective autophagy, which is inhibited by radiation. Source data are provided as a Source Data file.
