Fig. 5: RNA velocity, splicing and trajectories in scRNA-seq data of islets from adult human non-diabetic and T2D donors in HPAP-HIRN. | Nature Communications

Fig. 5: RNA velocity, splicing and trajectories in scRNA-seq data of islets from adult human non-diabetic and T2D donors in HPAP-HIRN.

From: Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene

Fig. 5

a Spliced and unspliced genes percentage in α-and β-subclusters in non-diabetic (ND) (left) and in T2D (right) human islet data from HPAP–HIRN. b Pseudotime, RNA velocity length and RNA velocity confidence in the α-and β-cell subclusters of human islets from non-diabetic (ND) donors in HPAP-HIRN dataset. c Pseudotime, RNA velocity length and RNA velocity confidence in the α-and β-cell subclusters of human islets from T2D donors in the HPAP-HIRN dataset. d PAGA trajectory with stochastic modeling for non-diabetic (left) and T2D islet data (right).

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