Fig. 4: Intermolecular interactions determining the ageing kinetic modulation. | Nature Communications

Fig. 4: Intermolecular interactions determining the ageing kinetic modulation.

From: Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-β-sheet formation

Fig. 4

Intermolecular frequency contact maps for FUS LCD homotypic contacts in pure FUS LCD condensates (a) and FUS LCD/(SYGSYEGS)3 mixtures (b). The pairwise residue-residue contact frequency is expressed in percentage in all panels. The homotypic LARKS-LARKS interactions are highlighted with a dashed box. c Intermolecular frequency contact maps of the different inserted peptides with the FUS LCD sequence in the condensate. The contacts are calculated between all residues of the inserted peptide and the FUS LCD sequence. Intermolecular frequency contact maps for TDP-43 LCD homotypic contacts in pure TDP-43 LCD condensates (d) and TDP-43 LCD/(SYGSYEGS)3 mixtures (e). The homotypic LARKS-LARKS interactions are highlighted with a dashed box. f Intermolecular frequency contact maps of the different inserted peptides with TDP-43 LCD. In panels (c) and (f), the LARKS of each protein sequence are highlighted with dashed squares.

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