Fig. 2: Deficiency of macrophage TIPE2 aggravates obesity and metabolic disorders in HFD-fed mice. | Nature Communications

Fig. 2: Deficiency of macrophage TIPE2 aggravates obesity and metabolic disorders in HFD-fed mice.

From: Obesity-associated macrophages dictate adipose stem cell ferroptosis and visceral fat dysfunction by propagating mitochondrial fragmentation

Fig. 2

a–e M-Tipe2+/+ and M-Tipe2-/- mice were fed with NCD or HFD for 25 weeks. Body weight change (a), glucose tolerance test (b) in mice with an overnight fast, insulin tolerance test (d) in mice with free access to food, together with corresponding area under the curve (c, e). f-i Representative images (f) of inguinal SAT (IngSAT), epididymal VAT (EpiVAT), liver of the mice, and ratios of IngSAT mass (g), EpiVAT mass (h), liver weight (i) to body weight. j–m Hepatic triglyceride (TG, j) and total cholesterol (TC, k) contents, representative H&E staining (l) and Oil Red O staining (m) in liver sections. Scale bars, 20 μm. n = 4 or 5 mice per group (a), n = 3 mice per group (b–e, g–k). Data are presented as mean ± s.e.m. #P < 0.05, ##P < 0.01, ###P < 0.001 (NCD-M-Tipe2+/+ vs. HFD-M-Tipe2+/+ in a, b, d); *P < 0.05, **P < 0.01, ***P < 0.001 (HFD-M-Tipe2+/+ vs. HFD-M-Tipe2-/-in a, b, d) determined by two-way (a,b,d), one-way ANOVA (c, e, g-k).

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