Fig. 5: Ligand-specific conformational changes.
From: Molecular mechanisms of thiazide-like diuretics-mediated inhibition of the human Na-Cl cotransporter
a Ligand-specific interactions with S533. The PTZ-bound (less CTD-interacting), IDP-bound, asymmetrical CTN-bound (less CTD-interacting), and symmetrical CTN-bound NCC structures are colored purple, pink, orange, and green, respectively. Polar interactions are shown as yellow dashed lines. b, c Ligand-specific conformational changes of TM10-12. The less CTD-interacting TMD subunits of PTZ-bound and asymmetrical CTN-bound structures are aligned to the TMD subunits of IDP-bound and symmetrical CTN-bound structures. The color scheme is the same as in (a). TM11 and TM12 are not shown in b for clarity.
