Fig. 7: Pupillary kinetics are conserved between the mouse and human.
From: Pupil size modulation drives retinal activity in mice and shapes human perception
A Average pupillary response to 3-s full-field flash stimulus in mice (top, N = 5 animals) and human (bottom, N = 3 volunteers), the dotted purple line highlighting peak pupil response coincident with mouse delayed ON RGC responses (see Figs. 1 and 2). B Pupillary constriction onset (left) and peak of constriction (right) for data in (A) (mean ± SEM) comparing mice (left, green) and human (right, orange). **p = 0.008 (two-sided t-test). C Average pupillary response to 2 Hz (left, red) or 0.55 Hz (right, blue) stimulation in mice (top, N = 5 animals) and humans (bottom, N = 3 volunteers). D Fast Fourier Transform (FFT) of pupillometry data in (C), showing no signal from the 2 Hz stimulus centered on 2 Hz (left, red), but a significant peak from the 0.55 Hz stimulus centered on 0.55 Hz (right, blue). E Percent of the entire FFT signal (above 0.25 Hz) at either 2 Hz (red) or 0.55 Hz (blue) for those respective stimuli, for mouse and human. ***p < 0.001 (one-way ANOVA) (N = 3 humans, 5 mice).
