Fig. 7: Hypothetical working model of how Ig-like binders prevent α-syn fibrils binding to cell surface and reduce its pathological activities. | Nature Communications

Fig. 7: Hypothetical working model of how Ig-like binders prevent α-syn fibrils binding to cell surface and reduce its pathological activities.

From: Design of Ig-like binders targeting α-synuclein fibril for mitigating its pathological activities

Fig. 7

Ig-like binders, such as L3D1, vRAGE, CD4 D1, and CAR D1, specifically bind to the acidic C-terminal of α-syn, thus inhibiting α-syn fibrils from attaching to cell membranes and further blocking the following pathological processes, including neuronal α-syn aggregation and neuroinflammation induced by α-syn fibrils in cellular models. The diagram is created in BioRender. Liu, C. (2025) https://BioRender.com/fvndt7o.

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