Fig. 3: Conformational state of TcMscS.
From: Lipid-mediated gating of a miniature mechanosensitive MscS channel from Trypanosoma cruzi
a Superposition of the protomer structures of TcMscS (green) and the open (pink, PDB: 2VV5) or closed (blue, PDB: 6RLD) EcMscS channel. The dashed lines indicate the membrane boundaries. b Superposition of the wild-type TcMscS structures in detergent and in lipid. c Ion conduction pores of TcMscS (left panel, green) and closed EcMscS (right panel, blue). d Comparison of the pore profiles of TcMscS (green) with the closed (blue) and open conformations (pink) of EcMscS. e Hydrophobicity of the central ion permeation pathway in TcMscS (left panel) and EcMscS (right panel).
