Fig. 7: Mild cognitive impairment in mice with EPOR deletion in MOL. | Nature Communications

Fig. 7: Mild cognitive impairment in mice with EPOR deletion in MOL.

From: Transcriptional dynamics of the oligodendrocyte lineage and its regulation by the brain erythropoietin system

Fig. 7

a Experimental outline of the behavioral test battery of CnpCre::EPOR mice. Behavioral characterization was started at the age of 9 weeks and completed at the age of 50 weeks. b Higher cognition was assessed in IntelliCage and cognition index per day in all challenges plotted. Below the graphs, a schematic outline of the IntelliCage paradigms is depicted; HAB: Habituation; PL: Place Learning; RL: Reversal Learning; MRL: Multiple Reversal Learning; EXT: Extinction; ELM: Episodic-like memory; CW: Clockwise; CCW: Counterclockwise; N numbers in bars; mean ± SEM; two-tailed two-sample t test for normal and two-tailed Mann-Whitney U test for non-normal distributions. Only statistically significant p-values were shown, the non-significant values were 0.0993 (PL), 0.4795 (MRL), 0.2786 (ELM acquisition), 0.6007 (ELM retrieval), 0.2053 (ELM rev acquisition), 0.7789 (ELM rev retrieval). A more detailed overview of the results can be found in supplementary table 5. Source data are provided as a Source Data file.

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