Fig. 4: SNP heritability and genetic correlations.
From: Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk
a Bar chart represents the SNP heritability of 15 BMFFs. The error bars represent the 95% confidence interval. The heritability was calculated using LDSC based on 1,097,459 independent SNPs from GWAS summary statistics, of the following sample sizes: Th8 (N = 39,007), Th9 (N = 38,937), Th10 (N = 39,144), Th11 (N = 39,178), Th12 (N = 39,172), Th (N = 38,715), L1 (N = 39,030), L2 (N = 39,151), L3 (N = 39,162), L4 (N = 39,121), L5 (N = 39,134), L (N = 38,897), LPF (N = 38,559), RPF (N = 38,560), and PF (N = 38,522). b The heatmap shows genetic correlations (bottom triangle) and phenotypic correlations (top triangle) between 15 BMFFs. Degree of correlation is indicated by the color legend, ranging from −1 to +1. Two-sided P values shown unadjusted are estimated using LDSC for genetic correlation. c Genetic correlations between 15 BMFFs and 13 clinical measures and ten clinical diseases. Degree of correlation is indicated by the color legend, ranging from −1 to +1. Two-sided P values shown are estimated using LDSC for genetic correlation. Only the correlation coefficient that survived Bonferroni correction is shown. P value <1.28 × 10−3 (0.05 divided by 13 clinical measures and three principal components) was considered statistically significant for analysis between BMFFs and measures. P value <1.67 × 10−3 (0.05 divided by ten clinical diseases and three principal components) was considered statistically significant for analysis between BMFFs and diseases. The exact P values were provided in Supplementary Data 25, 26. BMFF bone marrow fat fraction, Th thoracic vertebra, L lumbar vertebra, PF proximal femur, LPF left proximal femur, RPF right proximal femur, BMD bone mineral density, HDL−C high density lipoprotein cholesterol, LDL−C low density lipoprotein cholesterol, BMI body mass index, Hb hemoglobin concentration, WBC white blood cell count, PLT platelet count, RBC red blood cell count, RET reticulocyte count, AN anorexia nervosa, T2DM type 2 diabetes, MM multiple myeloma, MDS myelodysplastic syndrome, AA aplastic anemia.
