Fig. 5: Distribution of PRS and cumulative osteoporosis incidence stratified by PRS.
From: Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk
a–c Density plots show the distribution of PRS for participants with low, intermediate, and high BMFF that was defined based on the tertiles of normalized BMFF. PRS of left proximal femur (a), right proximal femur (b) and proximal femur (c) BMFF yielded discrimination for BMFFs. d–f Cox hazard proportional regression was utilized to compare osteoporosis incidence rates between low, intermediate, and high PRS groups with adjustment for age, sex, and BMI. Disease outcomes were identified based on ICD9 and ICD10. Strata based on PRS of left proximal femur (d), right proximal femur (e), and proximal femur (f) BMFF. Those in the first tertiles of PRS are depicted in blue, the second tertiles are depicted in orange, and the last tertiles are depicted in red. The darker shades represent the central estimate of the cumulative incidence (defined as the Kaplan–Meier survival estimate). The lighter shades represent the respective 95% CIs. The x-axis depicts years since enrollment in the UKB; the y-axis depicts cumulative incidence. BMFF bone marrow fat fraction, PF proximal femur, LPF left proximal femur, RPF right proximal femur, PRS polygenic risk score, HR hazard ratio, CIs confidence intervals.
