Fig. 5: In vivo establishment of the CDX model and the anti-tumor efficacy of HTHSG.
From: A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer
a Schematic of CDX model establishment and treatment. Created in BioRender. Zhao, J. (2025) https://BioRender.com/wo5g5bl. b Thermal images of CDX tumor-bearing mice during AMF exposure. c Body weight changes in each group of the CDX model. The data were presented as the mean ± SD (n = 5 mice per group). d Digital images of excised tumors from the CDX model. Scale bar: 1 cm. e Tumor volumes from colorectal CDX model mice in Groups 1, 2, 3, 4, 5, 6, and 7. The data were presented as the mean ± SD (n = 5 mice per group). Statistical differences were analyzed bya two-tailed unpaired Student’s t-test. (*p < 0.05, **p < 0.01). f Tumor weights from colorectal CDX model mice in Group 1, 2, 3, 4, 5, 6 and 7. The data were presented as the mean ± SD (n = 5 mice per group). Statistical differences were analyzed by two-tailed unpaired Student’s t-test. (*p < 0.05, **p < 0.01 and ***p < 0.001). g Immunohistochemical analysis of KI67, Cleaved Caspase 3, GPX4 and HSP70 of tumor slices in different groups. Scale bar: 100 μm. Each experiment was repeated five times independently with similar results. Source data are provided as a Source Data file.
