Fig. 7: Anti-tumor effects of HTHSG in orthotopic mouse models.
From: A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer
a Schematic of orthotopic rectal cancer mouse model establishment and treatment. Created in BioRender. Zhao, J. (2025) https://BioRender.com/9unaydd. b In vivo bioluminescence images of orthotopic rectal cancer mouse models before treatment. c Thermal images of orthotopic rectal cancer mice during AMF exposure. d In vivo bioluminescence images of orthotopic rectal cancer mice models after treatment. e In vivo CT images of orthotopic rectal cancer mice models during treatment. Each experiment was repeated five times independently with similar results. f Digital images of excised tumors from orthotopic rectal cancer mouse models. Scale bar: 1 cm. g Immunohistochemical analysis of KI67, Cleaved Caspase 3, GPX4 and HSP70 on tumor slices from different groups. Scale bar: 100 μm. Each experiment was repeated five times independently with similar results. Representative flow cytometry plots of DCs (h), CD4 + T cells (i), CD8 + T cells (j) and Treg cells (k) in the spleen after different treatments.
