Fig. 8: Feasible application of HTHSG.
From: A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer
a Schematic of HTHSG hydrospongel implantation and treatment in a beagle. Created in BioRender. Zhao, J. (2025) https://BioRender.com/juwc1cn. b Digital image of the guidewire placed in the designated position. c Digital image of the HTHSG hydrospongel placed into a Sengstaken-Blakemore Tube. d Digital image of HTHSG and Sengstaken-Blakemore Tube placed at the designated position in the dog’s bowel. e Digital image of HTHSG (with 3D-printed PLA bracket) and Sengstaken-Blakemore Tube. f Digital image of HTHSG with a bracket placed at the designated position in the dog’s bowel. g Digital image of a beagle exposed to AMF. h Thermal image of HTHSG during AMF exposure. i In vivo CT images of a beagle during treatment. j Defecation imaging of a beagle before treatment. k Defecation imaging of a beagle after treatment. Representative Masson trichrome staining images of the beagle internal anal sphincter (l) and external anal sphincter (m). Scale bar: 0.5 mm. n Representative H&E staining images of beagle major organs, including heart, liver, spleen, lung, and kidney of beagle. Scale bar: 100 μm. o Schematic of HTHSG hydrospongel implantation and treatment in a dummy enema training model. Created in BioRender. Zhao, J. (2025) https://BioRender.com/yanxf85. p Thermal images of dummy enema training model during AMF exposure. q Schematic of HTHSG hydrospongel implantation and treatment in a rabbit. Created in BioRender. Zhao, J. (2025) https://BioRender.com/gomd4sd. r Thermal images of rabbit during AMF exposure. s Representative Masson trichrome staining images of rabbit sphincter. Scale bar: 0.5 mm.
