Fig. 2: Crystal structure of empasiprubart. | Nature Communications

Fig. 2: Crystal structure of empasiprubart.

From: Randomized phase I trial outcomes show safe and sustainable inhibition of classical and lectin complement pathways by empasiprubart

Fig. 2

a Illustrative representation of the Fab-C2 Nt complex in the presence of a calcium ion (pink sphere). The anti-κ nanobody (kNb) is shown in yellow, empasiprubart VH in orange, empasiprubart VL in green, and C2 Nt (C2a) in gray. b Detailed view of interactions between the centrally positioned Ca2+ ion with both empasiprubart VH and C2 Nt main chain. Side chains of indicated residues are presented in sticks. Small red spheres are water molecules. Hydrogen bonds are shown as dotted lines. c View of the interaction between HCDR2 Tyr54 (stick representation) and the hydrophobic cavity of C2 (surface representation, red is more hydrophobic) (PDB Entry ID: 8ACI; https://doi.org/10.2210/pdb8ACI/pdb). C2 complement factor 2, CCP complement control protein, CL conserved light, HCDR2 heavy complementarity-determining region, Nt N-terminal, VH variable heavy, VL variable light.

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