Fig. 2: Cholecystectomy exacerbates colitis in AOM/DSS mouse model.
From: Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis
a DAI score of Sham+AOM/DSS and GBx+AOM/DSS mice at week 4 and 10 after AOM injection. b Representative macrograph of colons and colon length. c H&E staining of colon tissue (left) and histological score (right). Histological slides showed acute inflammation at 4 weeks and chronic inflammation at 10 weeks following AOM injection. The bottom scale bar is 200 μm, and the top scale bar is 20 μm. d–g Relative expression of ZO-1 (d), Occludin (e), IL-1β (f) and TNF-α (g) in colonic tissues. n = 5/group. Data are shown as the mean ± SEM. P values were determined by a two-tailed t test and were indicated in each figure. DAI, disease activity index; ZO-1, tight junction protein 1; IL-1β, interleukin-1β; TNF-α, tumor necrosis factor alpha. All data are representative of more than three independent experiments. Source data are provided as a Source Data file.
