Fig. 3: Cholecystectomy exacerbates colorectal tumorigenesis in a gut microbiota-dependent manner.
From: Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis
a Experimental design for patient FMT mouse model. b Representative images of mouse colons (n = 6/group). c Representative images of H&E staining (left) and semiquantitative analysis (right) (n = 6/group). H&E staining presented normal mucosa, dysplastic mucosae, and carcinoma in the colon tissues. d Schematic overview of mouse fecal FMT model. e Representative images of the colon (n = 5/group). f Representative images of H&E staining (left) and semiquantitative analysis (right) (n = 5/group). H&E staining showed normal, dysplastic mucosae and carcinoma in the colon tissues. g Representative images of the colon in the cohousing experiments (n = 7/group). h Representative images of H&E staining (left) and semiquantitative analysis (right) in each group (n = 7/group). H&E staining showed normal, dysplastic mucosae and carcinoma in the colon tissues. The bottom scale bar is 200 μm and the top scale bar is 20 μm for c, f, and h. Data are shown as the mean ± SEM. P values were determined by ANOVA. ns not significant, FMT fecal microbiota transplantation, Mo mono-housed, Co co-housed. Source data are provided as a Source Data file.
