Fig. 1: ALK RNA is expressed in multiple neoplastic histologies and has restricted expression in normal histologies. | Nature Communications

Fig. 1: ALK RNA is expressed in multiple neoplastic histologies and has restricted expression in normal histologies.

From: A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers

Fig. 1

A Neoplastic histologies considered outliers of ALK RNA expression defined as median at or greater than the 95th percentile of TPM or one sample at or greater than the 99th percentile of TPM in descending order. B Normal histology median ALK RNA expression compared to neuroblastoma. Data plotted as median log 2 transformed transcript per million (TPM) + 1 to account for tissues with a TPM of 0. Box plot center lines define median ALK RNA expression, box limits define the third quartile, and whiskers define the minimum and maximum values. Sample size of biologic tumor replicates, median TPM, mean TPM, and standard deviation of TPM are provided in Supplemental Tables 1–2.

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