Fig. 6: Deletion of motV increased inter-animal transmission.
From: Vibrio cholerae motility is associated with inter-animal transmission
Transmission assays were performed by randomly reassorting CD1 pups, challenging ~1/3 of the litter with the indicated strain of V. cholerae (seeds), and returning them to foster-dams with naïve littermates (contacts). 20 h later, transmission was determined by enumerating CFU in the SI. Animals per group are shown in (A). Experimental groups: WT, ΔmotV, and ΔcheY-3 n = 88 pups (9 litters) randomized between strains; ΔctxAB and ΔmotV ΔctxAB n = 60 pups (6 litters) randomized between strains. A Experimental results divided by litter. Uninfected contacts, 0 CFU detected; infected, ≥1 CFU identified. Two-sided Fisher’s exact test. B Seed SI CFU determined 20 h post inoculation. Geometric mean and standard deviation. C Contact SI colonization determined after 20 h of cohousing with seed animals. Geometric mean. Kruskal-Wallis test with Dunn’s multiple comparison correction. Source data are provided as a Source Data file. Parts of this figure were created in BioRender. Campbell, I. (2025) https://BioRender.com/7ac9055.
