Fig. 1: Schematic illustration of dual-key cooperatively activated DNA regulator for precise regulation of mitochondria-lysosome interactions. | Nature Communications

Fig. 1: Schematic illustration of dual-key cooperatively activated DNA regulator for precise regulation of mitochondria-lysosome interactions.

From: Dual-key cooperatively activated DNA regulator for controlling mitochondria-lysosome interactions

Fig. 1

After cellular internalization, the mitochondria-lysosome interaction regulator (DK-MLIR) binds mitochondria via TPP moiety. Then the DK-MLIR was cooperatively activated by light and endogenous glutathione (GSH) to form CD63 aptamer for lysosomal targeting and mitochondria-lysosome interactions regulation, resulting in mitochondrial fission and autophagy.

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