Fig. 7: Schematic of Eps15 and Dab2_320–495 interactions and phase separation.

A illustration of the complex interaction network between Eps15 and Dab2_320–495, including intra-molecular interactions within Eps15. Interactions are visualized with red dashed lines. B Cartoon of self-interactions within Eps15 and of interactions between Eps15 and Dab2_320–495. Eps15’s EH domains interact with Eps15_IDR and with Dab2_320–495. EH2 and EH3 tumble together. All three EH domains interact with the NPF motif within Dab2_320–495, while EH2 and EH3 are promiscuous binders. C The weak multivalent interaction network of the two IDRs with EH123 likely contributes to co-phase separation of Eps15 and Dab2_320–495. Eps15:Dab2 interactions are highlighted in red shading, and Eps15:Eps15 interactions are highlighted in pink shading.