Fig. 1: Prolong FO exposure suppresses food intake.
From: Prolonged exposure to food odors suppresses feeding via an olfactory bulb-to-hypothalamus circuit
a Schematic figure for experimental procedure and odor exposure paradigm. b Chow intake at 1, 2, 3 h from 6:30 pm to 9:30 pm in chow-fed male mice with or without chow-derived odor exposure. n = 21 mice in control group; n = 23 mice in chow odor group. c HFD intake at 1, 2, 3 h from 6:30 pm to 9:30 pm in HFD-fed male mice with or without chow-derived odor exposure. n = 9 mice per group. d Three-hour chow intake from 6:30 pm to 9:30 pm in chow-fed male mice treated with saline or ZnSO4. n = 6 mice per group. e Three-hour chow intake from 6:30 pm to 9:30 pm in chow-fed male mice treated with saline or methimazole. n = 18 mice in saline group and 12 mice in methimazole group. f Schematic figure for experimental procedure for repeated odor exposure. g Daily food intake (6:30 pm–9:00 am) in chow-fed male mice with or without repeated chow-derived odor exposure for 5 days. n = 5 mice per group. h Body weight change in chow-fed male mice with or without chow-derived odor exposure for 5 days. n = 5 mice per group. Two-way ANOVA with post hoc Sidak’s multiple comparisons in (b–e). Two-way Repeated Measures ANOVA with post hoc Sidak’s multiple comparisons in (g, h). Effect of Chow odor in (g), F (1, 8) = 7.861, #P < 0.05; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data are presented as mean ± SEM with individual data points in (b–e), and as mean ± SEM in (g, h). Source data are provided as a Source data file. The Schematics in (a) created in BioRender. He, Y. (2025) https://BioRender.com/95d0bwl.
