Fig. 1: Design and function of biohybrid microrobots for active pneumonia therapy.
From: Biomimetic magnetobacterial microrobots for active pneumonia therapy
A N3-labeling hybrid membrane nanoparticle CurNPs@2TM were attached to DBCO-labeling magnetic bacteria AMB-1 through click chemistry to form AR. B Schematic diagram of the application of AR in the treatment of pneumonia. After i.t. inhalation, the magnetic driven AR reach the alveoli, and under RMF, AR move and quickly neutralize inflammatory factors and PsV. Then, magnetically actuated AR penetrate the thick mucus layer to achieve efficient release and long-term retention of Cur. Under the regulation of Cur, the pneumonia microenvironment is alleviated, including the polarization of pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages. 2 M, TM, and 2TM refer to membranes derived from ACE2-293T cells, THP-1 cells, and their hybrid, respectively. DBCO is dibenzocyclooctyne. PsV denotes pseudovirus. IL-6 and GM-CSF are interleukin-6 and granulocyte-macrophage colony stimulating factor. ACE2 stands for angiotensin-converting enzyme 2.
