Fig. 1: Transcriptomic characterization of lineage-switched AML with the KMT2A rearrangement. | Nature Communications

Fig. 1: Transcriptomic characterization of lineage-switched AML with the KMT2A rearrangement.

From: Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement

Fig. 1

a Morphologic switching of LS from B-cell precursor ALL to monocytic AML (FAB: M5). Representative samples from patient LS AML2 are shown. May-Giemsa stain, ×400. b Schematic diagram showing sample collection and RNA-seq analysis of the inhouse cohort and deposited data. Most relapsed cases had samples taken at both disease presentation and relapse. c, d PCA distribution plots for each sample (Probe: 1500). The status (c) and fusion partner (d) of each sample are indicated. Pres: at disease presentation, Rel: at relapse. Source data are provided as a Source Data file. e Hierarchical clustering using Ward’s distance (Pearson), based on the 1500 most differentially expressed genes across nine LS AML samples and 54 LC AML samples. The optimal cluster number was accessed by plots in ConsensusClusterPlus (Supplementary Fig. 2c–f).

Back to article page