Fig. 3: Association between multidimensional social exposome and brain structure.
From: Social exposome and brain health outcomes of dementia across Latin America
a Whole-brain analysis for persons with Alzheimer’s disease (AD, purple) shows regions with significant associations between the multidimensional social exposome (MSE) and gray matter volume (GMV), highlighted by threshold-free cluster enhancement (TFCE) values. Circular barplot charts are included for the top cluster, indicating the percentage coverage of the top region within the cluster. Scatterplots illustrate the relationship between MSE scores and clusters’ GMV. b Whole-brain analysis for persons with frontotemporal lobar degeneration (FTLD, red) highlights regions significantly associated with MSE, with TFCE values similarly visualized. Corresponding scatterplots depict the associations between MSE scores and GMV for each identified cluster. In the scatter plots, each point represents an individual observation. The black line indicates the linear regression fit, and the shaded area represents the 95% confidence interval of the fit. ACG anterior cingulate gyrus, CCRU cerebellum crus, CER cerebellum lobule, FFG fusiform gyrus, IFGoperc inferior frontal gyrus, opercular part, IFGtriang inferior frontal gyrus, triangular part, INS insula, LING lingual gyrus, MFG middle frontal gyrus, ORBinf inferior frontal gyrus, orbital part, ORBmed medial orbital gyrus, PUT putamen, REC rectus gyrus, ROL rolandic operculum, SFG superior frontal gyrus, SFGdor superior frontal gyrus, dorsolateral, SFGmed medial superior frontal gyrus, VER vermis lobule. Source data are provided as a Source Data file.
