Fig. 1: Inactivating mutations in mexEFoprN are enriched among CF P. aeruginosa isolates. | Nature Communications

Fig. 1: Inactivating mutations in mexEFoprN are enriched among CF P. aeruginosa isolates.

From: Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivo

Fig. 1

a Percentage of acute respiratory ICU P. aeruginosa isolates with inactivating mutations or nonsynonymous single nucleotide polymorphisms (NS SNPs) in mexE, mexF, or oprN. b Percentage of CF P. aeruginosa isolates with inactivating mutations or NS SNPs in mexE, mexF, or oprN. c Genomic location of mexE and mexF inactivating mutations in clinical isolates. Blue indicates prevalence of mutation among ICU P. aeruginosa isolates and red indicates prevalence among CF P. aeruginosa isolates. Circular cladograms for ICU (d) and CF (e) P. aeruginosa isolates, respectively. Strains with WT mexE, mexF, and oprN are indicated by blue circles, strains with NS SNPs are indicated by green rectangles, strains with inactivating mutations are indicated by red dots, reference strains are indicated in black.

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