Fig. 1: Detour task and hippocampal remapping during detour.
From: Generative emergence of non-local representations in the hippocampus
a Diagram of experimental setup with 4 run sessions (Run 1–4) alternating with 4 sleep sessions (Sleep 1-4). b Example stable spike clusters from one tetrode across all sessions. c Place cells spatial tuning properties on detour and linear track segments. T1-T4L: linear tracks when not detoured. Kruskal-Wallis with Tukey-Kramer. (n = 1354, 1037, 464 for T1T3L, T2T4L, and DetSeg in firing rates and spatial information; n = 850, 643, 259 for T1T3L, T2T4L, and DetSeg in bi-directionality). d Place map similarity between various segment pairs from pre-detour and detour sessions. Cartoon: 9 configurations (columns) comparing segments bolded in pre-detour (top row) and detour (2nd row) sessions. Arrows mark the 2 running directions (D1/Dir1, direction 1 and D2/Dir2, direction 2). Place map similarities (Data) were compared with corresponding cell-ID shuffles (Shuffle; 3rd and 4th rows). Wilcoxon rank-sum tests. (n = 167, 195, 195, 201, 236, 158, 271, 163, 146 for direction 1; n = 179, 207, 198, 198, 240, 169, 274, 171, 151 for direction 2). e Firing rate similarity between detour segments and middle segments from the pre-detour session. We used the firing rate percentile among all the cells rather than the absolute firing rates to better visualize the distribution. Lines and shaded areas indicate mean and s.e.m. f Example population vector (PV) cosine similarity across spatial bins between pre-detour and detour sessions (top). PV similarity against detour segments from different segments (bottom) with each dot representing one animal, direction, and detour session (n = 20). Kruskal-Wallis with Tukey-Kramer. g Example place map sequence across individual T1-4 (continuous line rectangles) sorted based on Run1. Dashed line rectangle: detour segments. h Spearman rank-order correlation of place map sequences of Runs2–4 against Run1 for individual tracks, with each dot representing one animal and direction (n = 10). Student’s t test. Error bar plots were represented as mean ± s.e.m. In box plots, whiskers represented the 5th to 95th percentile range; the box represented the 25th to 75th percentiles, and the center dot indicated the median value. ***P < 0.001, *P < 0.05, n.s. = not significant. Source data are provided as a Source Data file.
