Fig. 6: NIR-II imaging of AD mouse brains. | Nature Communications

Fig. 6: NIR-II imaging of AD mouse brains.

From: Breaking shackles of molecular weight and emission for NIR-II fluorophores by regulating Columb attraction interaction

Fig. 6

A Schematic diagram of NIR-II imaging of Aβ plagues in AD mice, created by Hangzhou Sphere Ltd. B NIR-II brain imaging before and after intravenous injection of LS7 or ICG in WT and APP/PS1 mice at various ages and time points. 1000 nm LP filter. C Plot for time-dependent NIR-II fluorescence change of mouse brains post-injection of (C) LS7. D Plot for time-dependent NIR-II fluorescence change of mouse brains post-injection of ICG. E Ex vivo NIR-II fluorescence images for isolated WT and AD brains post-injection of LS7 for 30 min. F Intensity for image E. Data are presented as the mean ± SD (n = 3 independent biological samples) and analyzed by one-way ANOVA, ****P < 0.0001. G H&E staining and immunohistochemistry results of the WT and APP/PS1 brain tissues with different months of age. The experiment was repeated three times independently with similar results.

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