Fig. 6: Targeting BMAds in vivo and delivery of the LC plasmid in vitro. | Nature Communications

Fig. 6: Targeting BMAds in vivo and delivery of the LC plasmid in vitro.

From: Remodeling adipocytes’ lipid metabolism with a polycation loaded enzyme-active framework reverses osteoporotic bone marrow

Fig. 6

A Schematic diagram illustrating the experiments in which BMAds were targeted in vivo. B–D Flow cytometry (FCM) assessment and quantification of CZ@LC- and CZP@LC-targeted BMAds in vivo (n = 3 mice). E–G Fluorescence images and quantitative analysis of 3T3-L1 cells incubated with CZ@LC or CZP@LC for 0, 24 and 72 h (n = 3 independent experiments). H–J FCM evaluation and quantitative analysis of CZ@LC or CZP@LC uptake by 3T3-L1 cells (n = 3 independent experiments). The data were expressed as the means ± SDs. Statistical significance was determined by two-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001. (Mouse and syringe elements from Figdraw (www.figdraw.com) are used in this figure. Microtube and femur elements adapted from Servier Medical Art (https://smart.servier.com/) are used in this figure, licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/)).

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