Fig. 7: GelMa/Mg/DMF MSs promotes tissue repair and reconstruction in osteoporosis by inhibiting pyroptosis and remodeling the IME. | Nature Communications

Fig. 7: GelMa/Mg/DMF MSs promotes tissue repair and reconstruction in osteoporosis by inhibiting pyroptosis and remodeling the IME.

From: Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice

Fig. 7

Coronal images of the cranial defect after H&E staining A and Masson staining B 8 weeks after surgery. Scale bars: 100 μm. C Coronal images of the cranial defect after TRAP staining 8 weeks after surgery for the cranial defect. Scale bars: 100 μm and 20 μm. Coronal images of the cranial defect after immunohistochemistry for OCN D and GSDMD F 8 weeks after surgery for the cranial defect. Scale bars: 100 μm and 20 μm. Quantitative analysis of the percentage area of immunohistochemical staining for OCN E and GSDMD G 8 weeks after surgery for the cranial defect. (n = 5 samples). H Detection of inflammatory cytokines in the C57 serum at one week post-operation (n = 5 samples). I Images of cranial defects after immunofluorescence staining for Arg1+ (red) and iNOS+ (green). Scale bars: 100 μm and 20 μm. J Images of scalp tissue surrounding cranial defects after immunofluorescence staining for Arg1+ (red) and iNOS+ (green). Scale bars: 500 μm. K GelMa/Mg/DMF MSs inhibits pyroptosis and remodels the IME in osteoporosis. (created with BioRender.com) The data are presented as the means ± SD (n = 5 samples). Statistical significance was calculated by one-way ANOVA with Tukey’s post hoc test. Source data are provided as a Source Data file.

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