Fig. 5: Thermodynamic interactions between D(L)-Cu-SMOHs and HI. | Nature Communications

Fig. 5: Thermodynamic interactions between D(L)-Cu-SMOHs and HI.

From: Disassembly of chiral hydrogen-bonded frameworks into single-unit organometallic helices for enantioselective amyloid inhibition

Fig. 5

a ITC thermograms in the titration of D-Cu-SMOH into HI solution at 298.15 K. b ITC thermograms in the titration of L-Cu-SMOH into HI solution at 298.15 K. Fitting curves are obtained using the unit-point binding model. c The 3D structure and amino acid sequence of HI monomer. The key hydrophobic regions (α-helix and FFY regions) are highlighted by orange color. d The modified Stern-Volmer fitting FL quenching plot at varying temperatures for incubation of HI with D-Cu-SMOH. e The modified Stern-Volmer fitting FL quenching plot at varying temperatures for incubation of HI with L-Cu-SMOH. f Van’t Hoff plot fitting the thermodynamic interaction of HI with D-Cu-SMOH (\({{{\mathrm{ln}}}}{K}_{{{{\rm{a}}}}}=\frac{114.82 {{{\rm{J}}}}{{{{\rm{mol}}}}}^{-1}{{{{\rm{K}}}}}^{-1}}{{{{\rm{R}}}}}-\frac{14.73 {{{\rm{kJ}}}}{{{{\rm{mol}}}}}^{-1}}{{{{\rm{R}}}}T}\)) or L-Cu-SMOH (\({{{\mathrm{ln}}}}{K}_{{{{\rm{a}}}}}=\frac{119.39 {{{\rm{J}}}}{{{{\rm{mol}}}}}^{-1}{{{{\rm{K}}}}}^{-1}}{{{{\rm{R}}}}}-\frac{16.69 {{{\rm{kJ}}}}{{{{\rm{mol}}}}}^{-1}}{{{{\rm{R}}}}T}\)). Source data are provided as a Source Data file.

Back to article page