Fig. 1: Genomic analysis of ST167. | Nature Communications

Fig. 1: Genomic analysis of ST167.

From: Emergence of a carbapenem-resistant atypical uropathogenic Escherichia coli clone as an increasing cause of urinary tract infection

Fig. 1

a Bar graph displaying the human UTI/urine isolate proportion (%) from 2010 to 2024 for the five most sequenced E. coli STs deposited to EnteroBase in 2024 (source data in Supplementary Table 2). b A Maximum likelihood tree of 800 ST167 genomes. The tree was constructed from 109,894 recombination-free core-genome polymorphic sites by IQ-TREE (GTR + G model and 1000 ultrafast bootstraps; with CP083869.1 used as reference and ED1a as outgroup). Tree scale is representative of nucleotide substitutions per site. ST167 clades A, B and subclades C1 and C2 are shaded and were determined using fastbaps. The HC20 clusters are coloured on tip points of the branches. The pink stars on the branches of the major clade are indicative of >90% bootstrap support. The capsule type of the ST167 strains was determined using Kaptive 2.0. Antibiotic resistance genes carried by the ST167 strains was determined using AMRfinderplus, with red on the outermost ring indicating carriage of both carbapenem and cephalosporin resistance genes. c−f EnteroBase metadata was compiled to display bar charts for (c) collection year, (d) isolate source, 10/70 isolates were from UTI/urine sources for clade A, 60/314 for clade B, 7/38 for subclade C1 and 109/262 for C2, (e) carbapenem and cephalosporin resistance, and (f) capsule type.

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