Fig. 2: Virulence analysis of ST167. | Nature Communications

Fig. 2: Virulence analysis of ST167.

From: Emergence of a carbapenem-resistant atypical uropathogenic Escherichia coli clone as an increasing cause of urinary tract infection

Fig. 2

a Virulence factor heatmap of ST167. On the left is the phylogenetic tree of ST167 depicting the 800 genomes shown in Fig. 1a. The heatmap shows the presence and absence of the virulence factor marker genes; black indicates the virulence factor marker gene is present. The defined clades of the ST167 phylogeny are shaded. b EasyFig comparison of the type 1 fimbriae locus in CFT073 and representative complete genomes from clades A, B, C1 and C2. c−e Bacterial loads recovered from the (c) urine, (d) bladder and (e) kidneys of infected C57BL/6 mice expressed as median bacterial load per gram of tissue or ml of urine. Data are pooled from 2 independent experiments (n = 19 for strains MS25298 and MS25303; n = 12 for CFT073). Each symbol represents the bacterial load from an individual mouse at 24 h post infection. MS25298 and MS25303 are subclade C2 genomes from HC20 cluster 109409 and contain the KL124 capsule. Statistical significance was determined by an ordinary one-way ANOVA with the Dunnett correction applied; MS25298 and MS25303, respectively, were compared to CFT073.

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