Fig. 1: Correlation between Alzheimer’s disease biomarkers underscores the link between CSF t-tau levels and synaptic degeneration. | Nature Communications

Fig. 1: Correlation between Alzheimer’s disease biomarkers underscores the link between CSF t-tau levels and synaptic degeneration.

From: CSF total tau as a proxy of synaptic degeneration

Fig. 1

Correlation matrix shows significant two-sided Pearson’s coefficient (r) correlations after correcting for multiple comparisons (*Padj-value < 0.05) among established biomarkers of neurodegeneration (HCV, CSF NfL and t-tau), synaptic (CSF Ng and SNAP25), and tau tangles (tau PET) and Aβ (CSF Aβ1-42) pathologies in (left) cognitively unimpaired (n = 760) and (right) cognitively impaired (n = 932) individuals. All variables were log-transformed and z-scored, and HCV and CSF Aβ1-42 were inverted to indicate higher values indicate more pathology. Data points with sample sizes of 10 or fewer are omitted and displayed in white. Amyloid-β (Aβ). CSF (cerebrospinal fluid). Total-tau (T-tau). Classical neurodegeneration biomarkers: Hippocampal volume (HCV) and Neurofilament light chain protein (NfL). Classical synaptic biomarkers: Neurogranin (Ng) and Synaptosomal-associated protein 25 (SNAP25). Positron emission tomography (PET). Source data are provided as a Source Data file.

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