Fig. 2: CSF t-tau is more strongly associated with synaptic than neurodegeneration biomarkers. | Nature Communications

Fig. 2: CSF t-tau is more strongly associated with synaptic than neurodegeneration biomarkers.

From: CSF total tau as a proxy of synaptic degeneration

Fig. 2

Mean β estimates with 95% confidence intervals from linear regressions, adjusted for age, sex, and cohort, showing the association of CSF t-tau with biomarkers of neurodegeneration and synaptic degeneration in (left) cognitively unimpaired (n = 760) and (right) cognitively impaired (n = 932) individuals. Non-overlapping confidence intervals indicate statistically significant differences. All variables were log-transformed and z-scored. HCV was inverted, so higher values indicate more pathology. Cerebrospinal fluid (CSF). Total-tau (t-tau). Classical neurodegeneration biomarkers: Hippocampal volume (HCV) and CSF Neurofilament light chain protein (NfL). Classical synaptic biomarkers: CSF Neurogranin (Ng) and Synaptosomal-associated protein 25 (SNAP25). Source data are provided as a Source Data file.

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