Table 1 Demographic and key characteristics of participants across all cohorts

From: CSF total tau as a proxy of synaptic degeneration

Characteristics

CU (n = 760)

CI (n = 932)

P-value

Age, years mean (s.d.)

69.6 (7.5)

72.7 (7.7)

<0.0001

Females, n (%)

465 (61 %)

387 (42 %)

<0.0001

Race

 White, n (%)

700 (92 %)

883 (95 %)

0.028

 Unknown, n (%)

4 (0.5 %)

3 (0.3 %)

0.708

Ethnicity

 Not Hispanic/Latino, n (%)

733 (96 %)

901 (97 %)

0.790

 Unknown, n (%)

4 (0.5 %)

3 (0.3 %)

1.000

APOEε4 carriers, n (%)

265 (35 %)

516 (55 %)

<0.0001

Aβ-positive, n (%)

265 (35 %)

686 (74 %)

<0.0001

HCV, z-score mean (s.d.)

−0.02 (1.0)

−1.3 (1.4)

<0.0001

CSF Aβ1-42, z-score mean (s.d.)

−0.52 (1.1)

−1.4 (0.8)

<0.0001

CSF NfL, z-score mean (s.d.)

−0.002 (0.6)

1.3 (2.5)

<0.0001

CSF t-tau, z-score mean (s.d.)

0.15 (1.2)

1.0 (1.7)

<0.0001

CSF Ng, z-score mean (s.d.)

0.22 (1.2)

0.95 (1.4)

<0.0001

CSF SNAP25, z-score mean (s.d.)

0.28 (1.3)

0.91 (1.7)

<0.0001

  1. Values are mean (±s.d.) for continuous variables and n (%) for categorical variables. Continuous variables were tested with a two-sided Student’s t-test. Categorical variables were tested with Fisher’s exact test. Missing values: APOEε4 (n = 56), HCV (n = 91), NfL (n = 1064), Ng (n = 1078), SNAP25 (n = 1406). Hippocampal volume (HCV). Amyloid-β (Aβ). Neurofilament light protein (NfL). Neurogranin (Ng). P-values refer to the comparison between CU and CI.
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