Fig. 7: Longitudinal analysis within A+ sample over Braak meta-ROIs predicting mPACC score over time with. | Nature Communications

Fig. 7: Longitudinal analysis within A+ sample over Braak meta-ROIs predicting mPACC score over time with.

From: Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer’s Disease

Fig. 7

a Absolute baseline tau laterality; b Absolute baseline tau laterality after adjusting for tau load; c Absolute baseline Aβ laterality after adjusting for tau laterality, tau load, and Aβ load. The statistical analyses were performed using linear mixed effects models with random intercepts and slopes for time and participants (e.g., model depicted in panel a: mPACC ~ time * (agebaseline + sex + tau LIbaseline) + [1 + time | participant]). The statistical annotations indicate the standardized effect size and significance level of the interaction between time and baseline Aβ/tau laterality on cognitive test score, with p-values Bonferroni-corrected for the number of meta-ROIs tested in each model. For visualisation, regression lines represent the modelled mean cognitive test score with 95% confidence intervals, plotted for LIref and LIref + 2 SD of baseline Aβ/tau laterality, where LIref = 0 (i.e., perfect Aβ/tau symmetry). Aβ amyloid-beta, mPACC modified Preclinical Alzheimer Cognitive Composite, LI laterality index.

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