Table 1 Demographics

From: Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer’s Disease

  

Cross-sectional A+T+ (n = 452)

LA (n = 102; 22%)

S (n = 306; 68%)

RA (n = 44; 10%)

P-value

Age, years

73.4 (6.7)

73.5 (7.3)

72.1 (6.9)

0.462

Sex

M

46 (45%)

135 (44%)

18 (41%)

0.895

F

56 (55%)

171 (56%)

26 (59%)

 

Education, yearsa

12.7 (3.82)

12.5 (4.0)

13.4 (4.1)

0.354

Handednessb

R

85 (94%)

262 (94%)

41 (100%)

0.567

 

L

5 (6%)

16 (6%)

  
 

A

 

1 (<1%)

  

Diagnosis

CU

11 (11%)

40 (13%)

9 (21%)

0.511

MCI

39 (38%)

106 (35%)

12 (27%)

 

AD

52 (51%)

160 (52%)

23 (52%)

 

Braak stage

I-II

 

11 (4%)

 

<0.001

 

III-IV

21 (20%)

107 (35%)

6 (14%)

 
 

V-VI

81 (80%)

188 (61%)

38 (86%)

 

Temporal tau, SUVR

1.9 [1.7, 2.3]

1.7 [1.4, 2.3]

2.1 [1.8, 2.7]

<0.001

Temporal tau LI

−14.4 (3.7)

−0.4 (4.9)

14.7 (5.4)

<0.001

Neocortical Aβ, SUVRc

1.59 (0.20)

1.63 (0.23)

1.56 (0.23)

0.211

APOE ε4

0

32 (31%)

75 (25%)

16 (36%)

0.188

1

49 (48%)

182 (59%)

21 (48%)

 

2

21 (21%)

49 (16%)

7 (16%)

 

MMSEd

24.0 [21.0, 27.0]

25.0 [21.0, 27.0]

26.0 [22.7, 28.0]

0.328

mPACCe

−2.7 [−4.0, −1.7]

−2.6 [−3.8, −1.5]

−2.5 [−3.9, −1.2]

0.568

  1. Categorical variables have been presented as ‘count (%)’, normally distributed continuous variables as ‘mean (SD)’ and non-normally distributed variables as ‘median [interquartile range]’. All variables were compared between the tau asymmetry groups using either one-way ANOVA, Kurskal-Wallis, or Chi-squared test depending on the type and distribution of the data. LA left tau asymmetric, S tau symmetric, RA right tau asymmetric, M male, F female, R right-handed, L left-handed, A ambidextrous, CU cognitively unimpaired, MCI mild cognitive impairment, AD Alzheimer’s disease, SUVR standardized uptake value ratio, LI laterality index, Aβ amyloid-beta, MMSE Mini-Mental State Examination, mPACC modified Preclinical Alzheimer Cognitive Composite. Missing data for 10a, 42b, 219c, 1d, and 42e individuals.
Back to article page