Fig. 6: Cytotoxic TOX+CD8+ T cells infiltrate the brain in Ri-AIE. | Nature Communications

Fig. 6: Cytotoxic TOX+CD8+ T cells infiltrate the brain in Ri-AIE.

From: Neuron-reactive KIR+CD8+ T cells display an encephalitogenic transcriptional program in autoimmune encephalitis

Fig. 6

a Representative immunostaining of brain tissue from one aged-matched control. Brain tissue was stained for CD8 (yellow) and DAPI (blue). Bar length represents 20 μm. b Immunostaining of a brain lesion in autopsy tissue from Ri02. Left panels: Brain tissue was stained for TOX (red), CD8 (yellow) and nuclei (blue). Bar length represents 20 μm. Right panels: Brain tissue was stained for GZMB (magenta), CD8 (yellow), and nuclei (blue). Bar length represents 25 μm. c Quantification (cells/mm2) of brain-infiltrating CD8+ T cells in Ri02 (orange) vs aged-matched donors (n = 5, blue). Each dot represents one individual sample. Bar height represents the mean ± SEM. d Quantification of the proportion of TOX+CD8+ T cells among total brain-infiltrating CD8+ T cells for Ri02. e Quantification of the proportion of GZMB+CD8+ T cells among total brain-infiltrating CD8+ T cells for Ri02.

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